Gene: Cd47 - ENSMUSG00000055447 - Mus musculus (mouse)
proteinbearbetning och vikning (CANX, PSENEN) och det integrin-associerade protein, CD47, som modulerar cellaktivering och vidhäftning.
CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis. Among its related pathways are Integrin Pathway and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity. 2021-04-04 CD47 - CD47 molecule (human) This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal CD47 CD47 molecule Gene ID: 961, updated on 7-Mar-2021 Gene type: protein coding Also known as: IAP; OA3; MER6. Go to complete Gene record for CD47; … CD47 is a cell surface glycoprotein that helps mediate neutrophil transmigration across blood vessels.
0.18. -0.33. COL8A1. 0.47. -0.40. CD47.
Protein profiling in individuals before onset of anca-associated vasculitis. Annals of the Rheumatic Diseases, BMJ Publishing Group Ltd 2020, Vol. 79 : 372-372.
Methods. After the lentiviral CD47‐siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit‐8, and the apoptosis of stem cells of acute myeloid leukemia was Genes; CD47; CD47 (CD47 molecule) active profile. The Function of CD47.
10 Products The gene CD47 may have Genomic and Proteomic products available from Sigma-Aldrich.
These mutations are displayed at the amino acid level across the full length of the gene by default. View mouse Cd47 Chr16:49851328-49912503 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression Expression of CD47 in lung tissue. Antibody staining with HPA044659 and CAB016055 in immunohistochemistry. Gene name. CD47 (HGNC Symbol) Synonyms.
Gene ontology; Molecular function CD47 has a single Ig-like extracellular domain and five membrane spanning regions. The interaction between SIRPα and CD47 can be modified by endocytosis or cleavage of the receptor, or interaction with surfactant proteins.
Brief meaning
Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity. Among the various candidate genes involved in acute rejection, CD47 inhibits monocyte/macrophage-mediated phagocytosis by identifying the CD47 signal regulatory protein alpha (SIRP-alpha) as self/non-self. In contrast, antisense Cd47 knockdown or gene disruption resulted in a dose dependent accumulation of immature and mature NK cells in spleen. Results identify Cd47 as a cell-intrinsic and systemic regulator of NK cell homeostasis and NK cell function in responding to a viral infection.
Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRPα and
8 Apr 2016 Suppression of MYC in mouse tumors and human tumor cells caused a reduction in the levels of CD47 and PD-L1 messenger RNA and protein.
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23 Jun 2020 CD47 engagement of SIRPα results in the phosphorylation of cytoplasmic ITIM motifs by inhibitory protein tyrosine phosphatases, SHP-1 and
GenBank Accession AK164165, Cd47, 3.20, 10.66, 0.049. NM_016957, Hmgn2, 3.20 CD47 is the latest immuno-oncology target and multiple companies are 076 - Krystal Biotech's NOVEL Gene Therapy for Rare Diseases | Interview with WX Intestinal Gene Expression Profiling and Fatty Acid Responses to a High-fat Diet Defining the role of CD47 and SIRPα in murine B cell homeostasis. RNA/DNA extraction, reporter gene assays and gene expression profiling. cells and macrophages via inflammatory mediators and CD47 promotes tumour cell Acta Endocrinologica - 2018-01-01.
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52, RP11-74C13.3, Normalizer. 53, COG1, Normalizer. 54, CD47, Normalizer. 55, PLEKHB2, Normalizer. 56, RP11-343H5.6, Normalizer
IAP, MER6, OA3: Description. CD47 molecule (HGNC Symbol) Entrez gene summary. This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. By FISH, Lindberg et al. (1994) mapped the CD47 gene to chromosome 3q13.1-q13.2. Animal Model Lindberg et al. (1996) made observations in gene-targeted mice indicating that integrin-associated protein plays a key role in host defense by participating both in polymorphonuclear migration in response to bacterial infection and in polymorphonuclear activation at extravascular sites.